What medications should not be taken with Analgin?

Update Date: Source: Network

There is no general statement that aspirin cannot be taken with any other drugs, but it is not recommended to take it with the following drugs to avoid affecting its efficacy or increasing adverse reactions. 1. When aspirin is used in combination with acenocoumarol, dicoumarol, phenprocoumon, warfarin, etipamide, danaparoid, low molecular weight heparin, the risk of bleeding increases. 2. When used in combination with calcium channel blockers, the risk of gastrointestinal bleeding increases. 3. When used in combination with alendronate, the stimulatory effect on the gastrointestinal tract increases, so caution should be exercised when used in combination. 4. When aspirin is used in combination with ketoacid, gastrointestinal adverse reactions increase, and digestive tract ulcer, gastrointestinal bleeding, and/or perforation may occur. 5. Aspirin can increase the risk of ciclosporin poisoning, and renal dysfunction, biliary stasis, sensory abnormalities, etc. may occur when used in combination. 6. Aspirin can reduce the clearance rate of methotrexate, leading to methotrexate poisoning, and adverse reactions such as leukopenia, thrombocytopenia, anemia, toxic renal injury, and mucosal ulceration may occur. 7. When used in combination with lithium agents, the clearance rate of lithium decreases and the plasma concentration increases, which may lead to symptoms of lithium poisoning. 8. When aspirin is used in combination with fluoroquinolones such as ofloxacin and levofloxacin, it can inhibit the action of γ-aminobutyric acid, thereby increasing the risk of seizure. 9. Aspirin can interfere with the production of prostaglandins, reducing the antihypertensive and natriuretic effects of angiotensin-converting enzyme inhibitors and β-adrenergic blockers. 10. When used in combination with loop diuretics and thiazide diuretics, the diuretic and antihypertensive effects of diuretics are reduced. 11. When used in combination with potassium-sparing diuretics, the diuretic effect of the latter is reduced, and hyperkalemia may occur, which may also cause toxic renal injury. 12. When used in combination with sulfonylureas, the metabolism of sulfonylureas is inhibited, and the risk of hypoglycemia increases. 13. When used in combination with immunosuppressants, it may cause renal failure, and the mechanism of action is still unclear. In addition, aspirin is generally not the preferred drug of choice and is only used short-term in cases of urgent and severe illness without other effective drugs for treatment. Skin damage caused by this drug is common, and severe cases may require hospitalization. If skin rashes, itching, or other reactions occur during use of this drug, it should be discontinued immediately, and severe cases should seek immediate medical attention. This drug has a risk of causing anaphylactic shock. Patients may experience symptoms such as chest tightness, facial flushing, rash, dyspnea, cyanosis of the lips, profuse sweating, hypotension, confusion, loss of consciousness, and even death.